RNA Details
Disease Name
liver cirrhosis
Tissue
liver
RNA Symbol
mir-122
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
PCR; dual-lucimmunofluorescenceerase reporter assay etc.
Target
FN1
Pathway
NA
PubMed ID
Title
Identification of a novel TGF-B-miR-122-fibronectin 1/serum response factor signaling cascade and its implication in hepatic fibrogenesis
Year
2015
Function
Mir-122 directly inhibits the expression of fn1 by binding its 3 'untranslated region and indirectly reduces the transcription of a-sma and col1a1 by inhibiting the expression of serum response factor (srf).